This patient is more likely to display risk-reward behavior, which is strongly associated with addictive and depressive tendencies.
SUPPLEMENT
RECOMMENDATIONS
Addictive Tendencies: Acetyl-L-Carnitine Vitamin D3 Magnesium SAMe
Depressive or "Low Motivation" Tendencies: Vitamin D3 Magnesium Omega-3 SAMe (caution with slow COMT) Rhodiola (caution with the pharmaceutical classes: MAO inhibitors, dopamine agonists and antagonists)
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
Addictive Tendencies: Reduce caffeine and other stimulating substances Encourage incorporation of positive habits on a daily basis Recognize when referral is needed and have a list of appropriate resources ready
Depressive Tendencies: Encourage physical activity every day. Add more physical movement into daily routine Incorporate foods that boost motivation and morale (see best practices guide for examples) Encourage sunlight exposure every day Recognize when referral is needed and have a list of appropriate resources ready.
THE
DNA
COMPANY
2
Report:
Mood and Behavior
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Binging and Binge-Addiction Tendencies
Genes involved:
COMT, DRD2, MAO
RESULT + SUMMARY
This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS
No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
No Recommendation
THE
DNA
COMPANY
3
Report:
Mood and Behavior
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Anxiety
Genes involved:
COMT, ADRA2B, DRD2
RESULT + SUMMARY
This patient is at a medium level risk of displaying symptoms of anxiety and feelings of low self-worth. They are likely to see themselves as lesser to others and often exaggerate the impact of events in their lives.
SUPPLEMENT
RECOMMENDATIONS
Magnesium Bisglycinate L-theanine Deep Calm Optimizer Adaptogens: Ashwagandha, Tulsi, Rhodiola, Lavender Omega 3 Blood sugar regulation (chromium, ALA, low dose berberine) Vitamin B12 (see methylation genes)
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
Find a mindfulness or meditation technique one enjoys and start practicing it for 5 minutes every morning. Normalize anxiety - it is common, it can be managed. Understand triggers (people, foods, situations) and create habits that either self-soothe during those moments or enable exit. Recognize when referral is needed and have a list of appropriate resources ready.
THE
DNA
COMPANY
4
Report:
Mood and Behavior
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Burnout
Genes involved:
ADRA2B, 5HTTLPR, COMT
RESULT + SUMMARY
This patient is at an increased risk of susceptibility to burnout. They are likely to allow things to pile on top of them until it’s too late.
SUPPLEMENT
RECOMMENDATIONS
Magnesium Bisglycinate L-theanine Adaptogens: Ashwagandha, Tulsi, Rhodiola, Lavender, Licorice (implications to blood pressure) Omega 3 Vitamin B12 (see methylation genes)
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
If stressors cannot be changed, encourage reframing of how they are seen. Plan for rest, if possible in prevention and before burnout occurs. Increase capacity to meet stressors by daily investing in physical and mental health
THE
DNA
COMPANY
5
Report:
Mood and Behavior
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
ADHD
Genes involved:
COMT, DRD2, MAO, 5HTTLPR
RESULT + SUMMARY
This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS
No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
No Recommendation
THE
DNA
COMPANY
6
Report:
Mood and Behavior
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Coping Mechanisms
Genes involved:
5HTTLPR, COMT
RESULT + SUMMARY
This patient is more likely to identify habits, such as food or smoking, as coping mechanisms for stressful situations
SUPPLEMENT
RECOMMENDATIONS
Youtrients Deep Calm
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
Facilitate a practice to recognize when negative emotions are arising and enable choice to engage or step away. Consider incorporating a loving-kindness meditation. Consider daily incorporation of teas like lavender, chamomile, and lemon balm.
THE
DNA
COMPANY
7
Report:
Mood and Behavior
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Recommendations Response
Genes involved:
COMT, DRD2, ADRA2B, 5HTTLPR
RESULT + SUMMARY
This patient is more likely to be resistant to new recommendations, particularly those that they are unfamiliar with. They will ask more questions and be more hesitant with starting any new treatment plans. They are more likely to be influenced by what their friends and family tell them with regards to health and wellness.
SUPPLEMENT
RECOMMENDATIONS
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
Enact the concept of Docere - the doctor as the teacher. Share information, encourage questions and encourage your patient to discuss their health plan with those closest to them.
THE
DNA
COMPANY
8
Report:
Mood and Behavior
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Reduced Compliance to Recommended Protocols
Genes involved:
COMT, DRD2
RESULT + SUMMARY
This patient is more likely to display reduced compliance to recommended protocols due to becoming fatigued with following repetitive instructions
SUPPLEMENT
RECOMMENDATIONS
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
Collaborate on your plan and ensure there is variety in it to ensure maintained attention
THE
DNA
COMPANY
9
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Mood and Behavior
GENE
COMT Rs4680
GENOTYPE + DESCRIPTION
AA
Associated with lowest COMT activity and longest dopamine half-life
AG
Associated with moderate COMT activity and medial dopamine half-life
GG
Associated with highest COMT activity and shortest dopamine half-life
GENE
MAO Rs6323
GENOTYPE + DESCRIPTION
TT
Associated with lowest MAO activity and longest dopamine half-life
GT
Associated with moderate MAO activity and medial dopamine half-life
GG
Associated with highest MAO activity and shortest dopamine half-life
10
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Mood and Behavior
GENE
DRD2 Rs1800497
GENOTYPE + DESCRIPTION
AA
Associated with lowest expression of post-synaptic DRD2 receptors with lowest dopamine binding, post-synaptic activation and pleasure response
AG
Associated with moderate expression of post-synaptic neuronal DRD2 receptors with moderate dopamine binding, post-synaptic activation and pleasure response
GG
Associated with highest expression of post-synaptic neuronal DRD2 receptors with moderate dopamine binding, post-synaptic activation and pleasure response
GENE
ADRA2B INDEL
GENOTYPE + DESCRIPTION
II
Associated with normal desensitization of noradrenergic receptors, resulting in reduced/balanced memory of negative emotional events
ID
Associated with decreased desensitization of noradrenergic receptors, resulting in enhanced memory of negative emotional events (potentially poor responder to SNRIs)
DD
Associated with decreased desensitization of noradrenergic receptors, resulting in enhanced memory of negative emotional events (potentially poor responder to SNRIs)
11
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Mood and Behavior
GENE
5HTTLPR INDEL
GENOTYPE + DESCRIPTION
LL
Associated with optimal expression of the serotonin transporter with optimal serotonin secretion and re-uptake
LS
Associated with decreased expression of the serotonin transporter with dysregulated serotonin secretion and re-uptake (potentially poor responder to SSRIs)
SS
Associated with decreased expression of the serotonin transporter with dysregulated serotonin secretion and re-uptake (potentially poor responder to SSRIs)
GENE
TPH2 rs4570625
GENOTYPE + DESCRIPTION
TT
Reduced serotonin production and poor inhibition of negative emotional stimuli
GT
Reduced serotonin production and poor inhibition of negative emotional stimuli
GG
Normal serotonin production and regular inhibition of negative emotional stimuli*
*Please note: Epistatic studies have demonstrated that a unique risk haplotype results from carrying the G/G version of both the BDNF and TPH2 gene. Individuals with this unique combination may display symptoms of depressive tendencies, experience difficulty in managing negative emotions, and struggle with wider mood swings and disturbed eating and sleeping patterns.
12
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Mood and Behavior
GENE
BDNF Rs6265
GENOTYPE + DESCRIPTION
AA
Associated with suboptimal production and levels of brain-derived neurotrophic factor
AG
Associated with suboptimal production and levels of brain-derived neurotrophic factor
GG
Associated with optimal production and levels of brain-derived neurotrophic factor*
GENE
GENOTYPE + DESCRIPTION
*Please note: Epistatic studies have demonstrated that a unique risk haplotype results from carrying the G/G version of both the BDNF and TPH2 gene. Individuals with this unique combination may display symptoms of depressive tendencies, experience difficulty in managing negative emotions, and struggle with wider mood swings and disturbed eating and sleeping patterns.