CONFIDENTIAL
CLINICIAN'S OVERVIEW
Mood and Behavior
Report: Mood and Behavior
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Addictive and Depressive Tendencies
Genes involved:
COMT, DRD2, MAO
RESULT + SUMMARY

This patient is more likely to display risk-reward behavior, which is strongly associated with addictive and depressive tendencies.
SUPPLEMENT
RECOMMENDATIONS

Addictive Tendencies:
Acetyl-L-Carnitine
Vitamin D3
Magnesium
SAMe

Depressive or "Low Motivation" Tendencies:
Vitamin D3
Magnesium
Omega-3
SAMe (caution with slow COMT)
Rhodiola (caution with the pharmaceutical classes: MAO inhibitors, dopamine agonists and antagonists)
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Addictive Tendencies:
Reduce caffeine and other stimulating substances
Encourage incorporation of positive habits on a daily basis
Recognize when referral is needed and have a list of appropriate resources ready

Depressive Tendencies:
Encourage physical activity every day. Add more physical movement into daily routine
Incorporate foods that boost motivation and morale (see best practices guide for examples)
Encourage sunlight exposure every day
Recognize when referral is needed and have a list of appropriate resources ready.
Report: Mood and Behavior
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Binging and Binge-Addiction Tendencies
Genes involved:
COMT, DRD2, MAO
RESULT + SUMMARY

This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS

No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

No Recommendation
Report: Mood and Behavior
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Anxiety
Genes involved:
COMT, ADRA2B, DRD2
RESULT + SUMMARY

This patient is at a medium level risk of displaying symptoms of anxiety and feelings of low self-worth. They are likely to see themselves as lesser to others and often exaggerate the impact of events in their lives.
SUPPLEMENT
RECOMMENDATIONS

Magnesium Bisglycinate
L-theanine
Deep Calm Optimizer
Adaptogens: Ashwagandha, Tulsi, Rhodiola, Lavender
Omega 3
Blood sugar regulation (chromium, ALA, low dose berberine)
Vitamin B12 (see methylation genes)
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Find a mindfulness or meditation technique one enjoys and start practicing it for 5 minutes every morning.
Normalize anxiety - it is common, it can be managed.
Understand triggers (people, foods, situations) and create habits that either self-soothe during those moments or enable exit.
Recognize when referral is needed and have a list of appropriate resources ready.
Report: Mood and Behavior
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Burnout
Genes involved:
ADRA2B, 5HTTLPR, COMT
RESULT + SUMMARY

This patient is at an increased risk of susceptibility to burnout. They are likely to allow things to pile on top of them until it’s too late.
SUPPLEMENT
RECOMMENDATIONS

Magnesium Bisglycinate
L-theanine
Adaptogens: Ashwagandha, Tulsi, Rhodiola, Lavender, Licorice (implications to blood pressure)
Omega 3
Vitamin B12 (see methylation genes)
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

If stressors cannot be changed, encourage reframing of how they are seen.
Plan for rest, if possible in prevention and before burnout occurs.
Increase capacity to meet stressors by daily investing in physical and mental health
Report: Mood and Behavior
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

ADHD
Genes involved:
COMT, DRD2, MAO, 5HTTLPR
RESULT + SUMMARY

This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS

No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

No Recommendation
Report: Mood and Behavior
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Coping Mechanisms
Genes involved:
5HTTLPR, COMT
RESULT + SUMMARY

This patient is more likely to identify habits, such as food or smoking, as coping mechanisms for stressful situations
SUPPLEMENT
RECOMMENDATIONS

Youtrients Deep Calm
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Facilitate a practice to recognize when negative emotions are arising and enable choice to engage or step away.
Consider incorporating a loving-kindness meditation.
Consider daily incorporation of teas like lavender, chamomile, and lemon balm.
Report: Mood and Behavior
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Recommendations Response
Genes involved:
COMT, DRD2, ADRA2B, 5HTTLPR
RESULT + SUMMARY

This patient is more likely to be resistant to new recommendations, particularly those that they are unfamiliar with. They will ask more questions and be more hesitant with starting any new treatment plans. They are more likely to be influenced by what their friends and family tell them with regards to health and wellness.
SUPPLEMENT
RECOMMENDATIONS

DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Enact the concept of Docere - the doctor as the teacher. Share information, encourage questions and encourage your patient to discuss their health plan with those closest to them.
Report: Mood and Behavior
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Reduced Compliance to Recommended Protocols
Genes involved:
COMT, DRD2
RESULT + SUMMARY

This patient is more likely to display reduced compliance to recommended protocols due to becoming fatigued with following repetitive instructions
SUPPLEMENT
RECOMMENDATIONS

DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Collaborate on your plan and ensure there is variety in it to ensure maintained attention
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Mood and Behavior
GENE

COMT
Rs4680
GENOTYPE + DESCRIPTION

AA
Associated with lowest COMT activity and longest dopamine half-life
AG
Associated with moderate COMT activity and medial dopamine half-life
GG
Associated with highest COMT activity and shortest dopamine half-life

GENE

MAO
Rs6323
GENOTYPE + DESCRIPTION

TT
Associated with lowest MAO activity and longest dopamine half-life
GT
Associated with moderate MAO activity and medial dopamine half-life
GG
Associated with highest MAO activity and shortest dopamine half-life
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Mood and Behavior
GENE

DRD2
Rs1800497
GENOTYPE + DESCRIPTION

AA
Associated with lowest expression of post-synaptic DRD2 receptors with lowest dopamine binding, post-synaptic activation and pleasure response
AG
Associated with moderate expression of post-synaptic neuronal DRD2 receptors with moderate dopamine binding, post-synaptic activation and pleasure response
GG
Associated with highest expression of post-synaptic neuronal DRD2 receptors with moderate dopamine binding, post-synaptic activation and pleasure response

GENE

ADRA2B
INDEL
GENOTYPE + DESCRIPTION

II
Associated with normal desensitization of noradrenergic receptors, resulting in reduced/balanced memory of negative emotional events
ID
Associated with decreased desensitization of noradrenergic receptors, resulting in enhanced memory of negative emotional events (potentially poor responder to SNRIs)
DD
Associated with decreased desensitization of noradrenergic receptors, resulting in enhanced memory of negative emotional events (potentially poor responder to SNRIs)
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Mood and Behavior
GENE

5HTTLPR
INDEL
GENOTYPE + DESCRIPTION

LL
Associated with optimal expression of the serotonin transporter with optimal serotonin secretion and re-uptake
LS
Associated with decreased expression of the serotonin transporter with dysregulated serotonin secretion and re-uptake (potentially poor responder to SSRIs)
SS
Associated with decreased expression of the serotonin transporter with dysregulated serotonin secretion and re-uptake (potentially poor responder to SSRIs)

GENE

TPH2
rs4570625
GENOTYPE + DESCRIPTION

TT
Reduced serotonin production and poor inhibition of negative emotional stimuli
GT
Reduced serotonin production and poor inhibition of negative emotional stimuli
GG
Normal serotonin production and regular inhibition of negative emotional stimuli*
*Please note: Epistatic studies have demonstrated that a unique risk haplotype results from carrying the G/G version of both the BDNF and TPH2 gene. Individuals with this unique combination may display symptoms of depressive tendencies, experience difficulty in managing negative emotions, and struggle with wider mood swings and disturbed eating and sleeping patterns.
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Mood and Behavior
GENE

BDNF
Rs6265
GENOTYPE + DESCRIPTION

AA
Associated with suboptimal production and levels of brain-derived neurotrophic factor
AG
Associated with suboptimal production and levels of brain-derived neurotrophic factor
GG
Associated with optimal production and levels of brain-derived neurotrophic factor*

GENE

GENOTYPE + DESCRIPTION

*Please note: Epistatic studies have demonstrated that a unique risk haplotype results from carrying the G/G version of both the BDNF and TPH2 gene. Individuals with this unique combination may display symptoms of depressive tendencies, experience difficulty in managing negative emotions, and struggle with wider mood swings and disturbed eating and sleeping patterns.