The DNA Company - Client Report

CONFIDENTIAL

CLINICIAN'S OVERVIEW

Hormones, Fitness, and Body Type

Report: Hormones, Fitness, and Body Type

Patient: Kashif Khan- New test kit

Patient ID: MG6644

HEALTH CONCERN

Hormone Dominance

Genes involved:

CYP17A1, SRD5A2, CYP19A1, AR, UGT2B17, UGT2B15, CYP3A4

RESULT + SUMMARY

This patient is more likely to display androgen dominance. They are likely to carry a leaner or more muscular body type. Females tend to have smaller breasts and narrower hips. Males tend to have more defined jaw lines and a larger Adam’s Apple.

SUPPLEMENT

RECOMMENDATIONS

Females with Androgen Dominance are more susceptible to PCOS and this should be screened for.
Males with Androgen Dominance are more susceptible to prostate issues and this should be screened for.
Resveratrol
Fenugreek
Genistein
Lycopene
Saw Palmetto
Inositol (namely for PCOS)
Youtrients Blood Sugar Regulator (namely for PCOS)

DIET, LIFESTYLE, AND ENVIRONMENT

RECOMMENDATIONS

Avoid dairy products.

Report: Hormones, Fitness, and Body Type

Patient: Kashif Khan- New test kit

Patient ID: MG6644

HEALTH CONCERN

Workout Profile

Genes involved:

9P21, 1P21, NOS3

RESULT + SUMMARY

This patient is associated with a normal workout profile. They can perform equal parts cardiovascular and weight-bearing exercises as they have a normal or optimal response to oxidative stress caused by increased intensity or length in cardiovascular exercise. As always, they should be monitored to ensure they aren't overdoing any exercise, but they generally are expected to recover at a normal or optimal pace following a workout.

SUPPLEMENT

RECOMMENDATIONS

DIET, LIFESTYLE, AND ENVIRONMENT

RECOMMENDATIONS

Report: Hormones, Fitness, and Body Type

Patient: Kashif Khan- New test kit

Patient ID: MG6644

HEALTH CONCERN

Rest and Recovery Profile

Genes involved:

GSTT1, GSTP1, GSTM1, SOD2, GPX

RESULT + SUMMARY

This patient carries an optimal rest and recovery profile and can generally function optimally with up to 4 days of physical workouts in a 7 day week with adequate rest days between workouts.

SUPPLEMENT

RECOMMENDATIONS

DIET, LIFESTYLE, AND ENVIRONMENT

RECOMMENDATIONS

Report: Hormones, Fitness, and Body Type

Patient: Kashif Khan- New test kit

Patient ID: MG6644

HEALTH CONCERN

Cystic Acne

Genes involved:

CYP17A1, SRD5A2, CYP19A1, AR, UGT2B17, UGT2B15, CYP3A4

RESULT + SUMMARY

This patient is at an increased risk of cystic acne. Increased androgen levels can initiate higher sebum production throughout the body, which can result in increased acne development particularly on the back and facial areas.

SUPPLEMENT

RECOMMENDATIONS

Females with Androgen Dominance are more susceptible to PCOS and this should be screened for. Male with Androgen Dominance are more susceptible to prostate issues and this should be screened.

Resveratrol
Fenugreek
Genistein
Lycopene
Saw Palmetto
Sulforaphane
DIM (if acne is caused by estrogen)
Zinc

DIET, LIFESTYLE, AND ENVIRONMENT

RECOMMENDATIONS

Refine the products in your skincare toolkit and opt for green and chemical free products.
Avoid dairy products.
Avoid processed foods.

Report: Hormones, Fitness, and Body Type

Patient: Kashif Khan- New test kit

Patient ID: MG6644

HEALTH CONCERN

Cellulite

Genes involved:

CYP17A1, SRD5A2, CYP19A1, AR, UGT2B17, UGT2B15, CYP3A4

RESULT + SUMMARY

This patient carries a normal cellulite profile. Any occurrence of cellulite is more likely to be attributed to dietary, lifestyle, or environmental factors.

SUPPLEMENT

RECOMMENDATIONS

DIET, LIFESTYLE, AND ENVIRONMENT

RECOMMENDATIONS

Report: Hormones, Fitness, and Body Type

Patient: Kashif Khan- New test kit

Patient ID: MG6644

HEALTH CONCERN

Balding/Hair Thinning

Genes involved:

CYP17A1, SRD5A2, CYP19A1, AR, UGT2B17, UGT2B15, CYP3A4

RESULT + SUMMARY

This patient is at an increased risk of hair thinning or balding. Increased androgen levels can shorten the lifespan of hair follicles found on the head, whilst simultaneously increasing the presence of increased body hair (hirsutism).

SUPPLEMENT

RECOMMENDATIONS

Tocotrienol
Fenugreek
Saw Palmetto
EGCG
DIM

DIET, LIFESTYLE, AND ENVIRONMENT

RECOMMENDATIONS

Add fenugreek to your daily diet
Avoid excessive use of hair products

Report: Hormones, Fitness, and Body Type

Patient: Kashif Khan- New test kit

Patient ID: MG6644

HEALTH CONCERN

Estrogen Toxicity

Genes involved:

CYP1B1, CYP1A1, CYP3A4

RESULT + SUMMARY

This patient is at an increased risk of estrogen toxicity. They are more likely to be predisposed to health concerns such as endometriosis, PMS, heavy bleeding, infertility, PCOS, and severe menopausal symptoms

SUPPLEMENT

RECOMMENDATIONS

DIM
I3C
Sulforaphane
Curcumin
Female Hormone E Support
Detox Optimizer

DIET, LIFESTYLE, AND ENVIRONMENT

RECOMMENDATIONS

Reconsider estrogen-based contraception such as the pill or hormone-coated IUDs. Opt for non-hormone based contraception instead.
Closely monitor any hormone supplementation such as BHRT
Avoid use of plastics which can act as endocrine disruptors and further exaggerate toxicity
Add cruciferous vegetables like broccoli, cauliflower, and kale to their daily diet

Makes a(n) INCREASED amount of testosterone

Clears out androgens at a(n) DECREASED rate

Experiences INCREASED impact of androgens through INCREASED binding

Converts a(n) DECREASED amount of testosterone into DHT

Converts a(n) DECREASED amount of testosterone into estrogen

Converts a(n) DECREASED amount of estrogens into 20He

Converts a(n) DECREASED amount of estrogens into 40He

Converts a(n) DECREASED amount of estrogens into 16aOHe

Eliminates harmful estrogen metabolites via COMT at a(n) INCREASED rate

Eliminates harmful metabolite byproducts in a(n) Suboptimal manner via glutathionization

Eliminates harmful metabolite byproducts in a(n) INCREASED manner via glutathionization

Has a(n) Suboptimal anti-inflammatory response to the presence of estrogen metabolites

Androgen Dominant

Decreased

Patient: Kashif Khan- New test kit

Patient ID: MG6644

Report: Hormones, Fitness, and Body Type

GENE

GSTT1
CNV
(# of copies)

GENOTYPE + DESCRIPTION

Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS

Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS

Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS

GSTM1
CNV
(# of copies)

Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS

Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS

Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS

Patient: Kashif Khan- New test kit

Patient ID: MG6644

Report: Hormones, Fitness, and Body Type

GENE

GSTP1
rs1695

GENOTYPE + DESCRIPTION

Associated with optimal enzyme function and optimal clearance of substrates and reactive oxygen species

Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species

SOD2
rs4880

Associated with optimal catalytic activity and optimal clearance of free radicals within the mitochondria

Associated with 30 to 40 percent reduction in catalytic activity, with increased susceptibility to oxidative stress within the mitochondria

Associated with suboptimal catalytic activity (70 percent reduction) with increased susceptibility to oxidative stress within the mitochondria

Patient: Kashif Khan- New test kit

Patient ID: MG6644

Report: Hormones, Fitness, and Body Type

GENE

GPX
rs1050450

GENOTYPE + DESCRIPTION

Associated with faster conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen

Associated with medium conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen

Associated with slower conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen

9P21
rs10757278
rs10757274
rs4977574

0-1G

Associated with lowest risk of coronary artery disease and ischemic stroke

2-3G

Associated with moderately increased risk of coronary artery disease and ischemic stroke

4-6G

Associated with increased risk of coronary artery disease and ischemic stroke

Patient: Kashif Khan- New test kit

Patient ID: MG6644

Report: Hormones, Fitness, and Body Type

GENE

NOS3
rs1799983

GENOTYPE + DESCRIPTION

Optimal NOS response to vascular/blood flow-shear force with appropriate nitric oxide bioavailability

Intermediate NOS response vascular/blood flow-shear force with moderate nitric oxide bioavailability

Reduced NOS response to vascular/blood flow-shear force with decreased nitric oxide bioavailability

CYP17A1
rs743572

Associated with low CYP17A1 expression and a balanced hormone profile. No association to increased risk of hormone-related health concerns

Associated with increased CYP17A1 expression and hormone dominance. Potentially associated with an increased risk of hormone-related health concerns.

Patient: Kashif Khan- New test kit

Patient ID: MG6644

Report: Hormones, Fitness, and Body Type

GENE

SRD5A2
rs523349

GENOTYPE + DESCRIPTION

Associated with reduced enzyme activity and reduced conversion of testosterone to DHT, minimizing risk associated with high DHT levels

Associated with moderate enzyme activity and moderate conversion of testosterone to DHT, with potential risk associated with high DHT levels

UGT2B17
CNV

Associated with increased enzyme activity and decreased concentrations of circulating testosterone and estradiol levels. Associated with low BMD and increased risk for osteoporosis

Associated with moderate enzyme activity and moderate concentrations of circulating testosterone and estradiol levels

Associated with absent enzyme activity and increased concentrations of circulating testosterone and estradiol levels

Patient: Kashif Khan- New test kit

Patient ID: MG6644

Report: Hormones, Fitness, and Body Type

GENE

UGT2B15
rs1902023

GENOTYPE + DESCRIPTION

Associated with increased glucuronidation of androgens and androgen metabolites, including DHT

Associated with moderate glucuronidation of androgens and androgen metabolites, including DHT

Associated with reduced glucuronidation of androgens and androgen metabolites, including DHT

CYP3A4
rs2740574

Associated with decreased enzyme activity, decreased production of 16α-OH-estrogen metabolites, and decreased catabolism of testosterone.

Associated with increased enzyme activity, increased production of 16α-OH-estrogen metabolites, and increased catabolism of testosterone.

Patient: Kashif Khan- New test kit

Patient ID: MG6644

Report: Hormones, Fitness, and Body Type

GENE

CYP19A1
rs10046

GENOTYPE + DESCRIPTION

Associated with reduced CYP19A1 expression and enzyme activity with reduced levels of estrogens and estrogen to androgen ratios, especially in postmenopausal women

Associated with moderate CYP19A1 expression and enzyme activity with moderately reduced levels of estrogens and estrogen to androgen ratios, especially in postmenopausal women

Associated with increased CYP19A1 expression and enzyme activity with increased levels of estrogens and estrogen to androgen ratios, especially in postmenopausal women

AR
rs6152

Associated with reduced binding of androgens to the androgen receptor and reduced androgenization

Associated with optimal binding of androgens to the androgen receptor and increased androgenization

Patient: Kashif Khan- New test kit

Patient ID: MG6644

Report: Hormones, Fitness, and Body Type

GENE

CYP1A1
Rs1048943

GENOTYPE + DESCRIPTION

Associated with decreased enzyme activity and decreased production of 2-OH-estrogen metabolites. Also associated with low enzyme inducibility upon exposure to toxins with reduced risk of toxic intermediate and ROS accumulation

Associated with increased enzyme activity and increased production of 2-OH-estrogen metabolites. However, also associated with increased enzyme inducibility upon exposure to toxins with increased risk of toxic intermediate and ROS accumulation

CYP1B1
Rs1056836

Associated with decreased enzyme activity, decreased production of 4-OH-estrogen metabolites, and potentially decreased DNA damaging events (with inducing environmental factors).

Associated with increased enzyme activity, increased production of 4-OH-estrogen metabolites, and potentially increased DNA damaging events (with inducing environmental factors).